allogeneic stem cell transplant precautions

To prepare for transplant, your child will go through a process called conditioning, or the preparative regimen. In some cases, it is possible to use cells from a parent or family member who is a 'half-match.' This type of transplant is called a haploidentical (half-matched) transplant. Mismatched donor transplants are fairly common, and many are successful.Īfter the donor is found, the stem cells will be collected from the donor and processed for the transplant. If a good match can't be found, the doctor may suggest using a mismatched donor, which is a donor who is a close, but not exact, HLA match.Unrelated donors are found through the Be the Match Registry of the National Marrow Donor Program. If no relatives are a good match, the cells may come from a volunteer donor who is well matched.Since genetic markers are inherited from parents, a biological brother or sister is the most likely the best match.If the donor cells are not well-matched to your child's HLA, your child's cells and the donor cells may attack each other.ĭoctors will also consider the donor's health and medical history. These markers are on the surface of most cells and play an important part in the immune system. The donor can be a relative or unrelated to the patient.ĭonor matching means finding a donor whose cells have similar genetic markers. The transplant team will coordinate the donor search to find a matched donor.

The first step in allogeneic transplant is to find a person to donate healthy stem cells.

Allogeneic stem cell transplant precautions